Ganciclovir mecanismo de accion pdf merge

It works by preventing the spread of cmv disease or slowing the growth of cmv. If you are 65 or older, use ganciclovir systemic with care. Nov 09, 2018 ganciclovir is an antiviral drug that slows the growth and spread of the cytomegalovirus cmv. In addition, ganciclovir triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral dna synthesis by a second route.

Esse mecanismo pode prevenir a doenca causada pelo citomegalovirus em pacientes com sistema imunologico debilitado ou pode diminuir a progressao da retinite. Ganciclovir is also used to prevent cmv disease in people with immunosuppression due to an organ transplant. O ganciclovir sodico e preparado como um po liofilizado esteril com uma solubilidade em agua excedendo 100 mgml. Ganciclovir is used to treat cmv retinitis in people with immunosuppression caused by hiv or aids. Ganciclovir is also used to prevent cmv disease in people with. Ganciclovir e contraindicado a pacientes com hipersensibilidade ao ganciclovir, valganciclovir ou qualquer outro componente da formula. Find patient medical information for ganciclovir ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus cmv gene ul97 during infection. It is widely used for the treatment of cmv infections among patients with impaired cellmediated immunity, particularly persons with poorly controlled and advanced hivaids, and recipients of solid organ and bone marrow transplantation, who are at high risk for invasive cmv. Cymevene, ganciclovir, infeccion por cmv, solucion, roche, rx. Ganciclovir dosificacion, efectos secundarios infosida. Ganciclovir indicaciones, dosificacion, presentacion. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into dna and preferentially inhibits viral dna polymerases more than cellular dna polymerases. Ganciclovir is an antiviral drug that slows the growth and spread of the cytomegalovirus cmv.

Ganciclovir is eliminated primarily through the kidneys and excreted as active drug in the urine. Tell your doctor if you have or have ever had anemia red blood cells do not bring enough oxygen to all parts of the body. Dec 21, 2018 whether ganciclovir can harm a human baby has not been fully studied. Cytoveneiv ganciclovir, formulated as monosodium salt, using sodium hydroxide as a salt forming agent, is a sterile white to offwhite lyophilized powder. Ganciclovir is in a class of medications called antivirals. Dose adjustment is recommended for patients with renal insufficiency. In a study of ganciclovir for injection treatment of life or sightthreatening cmv disease in immunocompromised patients, 121 of 314 patients had cmv cultured within 7 days prior to treatment and sequential posttreatment viral cultures of urine, blood, throat andor semen. A pregnancy test will be done before you start ganciclovir systemic to show that you are not pregnant. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate, which is present in 10fold greater. Ganciclovir is widely distributed throughout the body and achieves csf concentrations that are 24% to 70% of plasma concentrations.

Find patient medical information for ganciclovir sodium intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cymevene ganciclovir sodico antiviroticos identificacao do. Ganciclovir may lower the number of all types of cells in your blood, causing serious and lifethreatening problems. Ganciclovir is a prescription medicine approved by the u. To prevent pregnancy while taking ganciclovir, women should use the birth control of their choice and men should use condoms during treatment and for 90 days after ending treatment. Ganciclovir is also fdaapproved for the prevention of cmv disease in recipients of organ transplants who are at risk for cmv diseases. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate dgtp incorporation into dna and preferentially inhibits viral dna polymerases more than cellular dna polymerases.

Ganciclovir side effects, dosage, interactions drugs. Ganciclovir is also used to prevent cytomegalovirus cmv disease in people who have acquired immunodeficiency syndrome aids or who have received an organ transplant and are at risk of cmv disease. Composicion, indicaciones, presentacion y contraindicaciones. Ganciclovir is a white to offwhite crystalline powder with a molecular formula of c 9 h n 5 0 4 and a molecular weight of 255. Ganciclovir is used to treat cmv retinitis in people with immunosuppression caused by.